acatweasel
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Thanks Mr Starfarer, that article link was very useful. I’ve had a look at the item and linked articles, and I’m sure that will be very useful work in treating the disease, vaccines production, etc. At the moment they have a lot of work to do to confirm the observations they have on immune response and a variety of symptoms. It’s going to take a while to get to the bottom of this work.
If you can stand the thoughts of Chairman Mark here, then read on. Note that I am often wrong, as my wife tells me every day, so don’t read this as gospel.
I’m having trouble believing that the virus can directly cause some of the situations being observed. It appears to me that many of the items being seen are secondary effects. Example: blood clotting. Is the virus transplanting genetic material/enzymes to cause that directly? Answer: probably not. Why/how would it? Viruses don’t carry that much genetic material, and are successful because they are very good at the reproductive job in hand.
Scenario 1 -Virus arrives in respiratory tract. Hijacks, replicates itself and destroys host cells. Histamine released by mast and basophil cells in response to cell damage in the respiratory tract. Among other things blood vessels widen and inflammatory response starts. White Blood Cells of all types drawn to the area and they are looking for trouble. In this particular case the patient is young/strong/has previous experience dealing with a close relative to COVID-19. The WBCs chat amongst themselves, refer back to central command to refine antibodies and the killer cells, and launch the assault. Virus beaten in a matter of hours. WBCs are now circulating in the bloodstream that have this virus’s number should it appear elsewhere. Memory immune cells created.
Little damage, asymptomatic, maybe a light cough and bit of a temperature, lifelong immunity. Job done.
Scenario 2 – Same deal as above up until “In this particular case” and now the patient is old/immunocompromised/otherwise ill, or has no previous experience of dealing with COVID-19s relatives. The WBC chat consists of “What is this?” and starts trials on antibody and killer cell development. By the time the immune response is developed enough to deal with it, the virus has infected a lot of your respiratory linings and bacteria are setting up to give you pneumonia. The virus is circulating unopposed in your bloodstream.
From the evidence so far, I can’t determine if the virus can infect similar tissues, such as organ envelopes, blood vessels, etc. Maybe not, but the virus will now be detected elsewhere just because it is circulating.
By this time, you have a ventilator tube in your throat due to impaired lung function and your immune system has worked out an effective response. Unfortunately, the battle has turned into a war. Your own killer T-cells are destroying large numbers of infected cells and increasing the damage in their attempts to beat the virus, particularly in your airways and the associated blood vessels around them.
Your other systems are trying to repair the damage. Clotting agents are being produced locally, but some excess circulates in your bloodstream and produces clots in the poorly fed extremities of your body. Not only are you very sick, but to cap it all your feet hurt.
Not good, where’s that vaccine?
If you can stand the thoughts of Chairman Mark here, then read on. Note that I am often wrong, as my wife tells me every day, so don’t read this as gospel.
I’m having trouble believing that the virus can directly cause some of the situations being observed. It appears to me that many of the items being seen are secondary effects. Example: blood clotting. Is the virus transplanting genetic material/enzymes to cause that directly? Answer: probably not. Why/how would it? Viruses don’t carry that much genetic material, and are successful because they are very good at the reproductive job in hand.
- Shake hands with host cell and get invited in
- Hijack host cell to become virus factory
- Burst cell open and spread more viruses
Scenario 1 -Virus arrives in respiratory tract. Hijacks, replicates itself and destroys host cells. Histamine released by mast and basophil cells in response to cell damage in the respiratory tract. Among other things blood vessels widen and inflammatory response starts. White Blood Cells of all types drawn to the area and they are looking for trouble. In this particular case the patient is young/strong/has previous experience dealing with a close relative to COVID-19. The WBCs chat amongst themselves, refer back to central command to refine antibodies and the killer cells, and launch the assault. Virus beaten in a matter of hours. WBCs are now circulating in the bloodstream that have this virus’s number should it appear elsewhere. Memory immune cells created.
Little damage, asymptomatic, maybe a light cough and bit of a temperature, lifelong immunity. Job done.
Scenario 2 – Same deal as above up until “In this particular case” and now the patient is old/immunocompromised/otherwise ill, or has no previous experience of dealing with COVID-19s relatives. The WBC chat consists of “What is this?” and starts trials on antibody and killer cell development. By the time the immune response is developed enough to deal with it, the virus has infected a lot of your respiratory linings and bacteria are setting up to give you pneumonia. The virus is circulating unopposed in your bloodstream.
From the evidence so far, I can’t determine if the virus can infect similar tissues, such as organ envelopes, blood vessels, etc. Maybe not, but the virus will now be detected elsewhere just because it is circulating.
By this time, you have a ventilator tube in your throat due to impaired lung function and your immune system has worked out an effective response. Unfortunately, the battle has turned into a war. Your own killer T-cells are destroying large numbers of infected cells and increasing the damage in their attempts to beat the virus, particularly in your airways and the associated blood vessels around them.
Your other systems are trying to repair the damage. Clotting agents are being produced locally, but some excess circulates in your bloodstream and produces clots in the poorly fed extremities of your body. Not only are you very sick, but to cap it all your feet hurt.
Not good, where’s that vaccine?
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